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AZ 3146, Tocris Bioscience™

Product Code. 18095432
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent and selective Mps1 kinase inhibitor

Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Chemical Identifiers

CAS 1124329-14-1
Molecular Formula C24H32N6O3
Molecular Weight (g/mol) 452.559
InChI Key YUKWVHPTFRQHMF-UHFFFAOYSA-N
Synonym 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yl oxy-phenyl amino-7-methyl-7,9-dihydro-8h-purin-8-one, 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yloxy phenylamino-7-methyl-7h-purin-8 9h-one, 9-cyclopentyl-7,9-dihydro-2-2-methoxy-4-1-methyl-4-piperidinyl oxy phenyl amino-7-methyl-8h-purin-8-one, 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yl oxy phenyl amino-7-methylpurin-8-one, 8h-purin-8-one, 9-cyclopentyl-7,9-dihydro-2-2-methoxy-4-1-methyl-4-piperidinyl oxy phenyl amino-7-methyl, au5, az hplc, 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yl oxyanilino-7-methylpurin-8-one, 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yl oxy phenyl amino-7-methyl-7,9-dihydro-8h-purin-8-one, 9-cyclopentyl-2-2-methoxy-4-1-methylpiperidin-4-yl oxy phenyl amino-7-methyl-7h-purin-8 9h-one
PubChem CID 56973724
IUPAC Name 9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one
SMILES CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC

Specifications

Quantity 10 mg
Formula Weight 452.55
Percent Purity >99%
Chemical Name or Material AZ 3146
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