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Tocris Bioscience™ API-2
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
Brand: Tocris Bioscience™ 2151/10
328.46 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.Specifications
| 99% | |
| 35943-35-2 | |
| Triciribine, NSC 154020, TCN | |
| API-2 | |
| API-2 |
| 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine | |
| Room Temperature | |
| 10 mg | |
| M.W. (Observed): 320.31 |
For Research Use Only