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ANA 12, Tocris Bioscience™

Product Code. 30001631
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

TrkB receptor antagonist

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

Chemical Identifiers

CAS 219766-25-3
Molecular Formula C22H21N3O3S
Molecular Weight (g/mol) 407.49
MDL Number MFCD00117444
InChI Key TUSCYCAIGRVBMD-UHFFFAOYNA-N
PubChem CID 2799722
IUPAC Name N-{2-[(2-oxoazepan-3-yl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide
SMILES O=C(NC1=CC=CC=C1C(=O)NC1CCCCNC1=O)C1=CC2=CC=CC=C2S1

Specifications

Quantity 10 mg
Synonym ana-12, ana 12, n-2-hexahydro-2-oxo-1h-azepin-3-yl amino carbonyl phenyl-benzo b thiophene-2-carboxamide, trkb antagonist, n-2-2-oxoazepan-3-yl carbamoyl phenyl-1-benzothiophene-2-carboxamide, maybridge1_001394, ana12, ana hplc, n-2-2-oxoazepan-3-yl carbamoyl phenyl benzo b thiophene-2-carboxamide
Formula Weight 407.49
Percent Purity >99%
Chemical Name or Material ANA 12
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