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  7. AG 490, Tocris Bioscience™

AG 490, Tocris Bioscience™

Product Code. 18034002
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

Selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.

Chemical Identifiers

CAS 133550-30-8
Molecular Formula C17H14N2O3
Molecular Weight (g/mol) 294.31
InChI Key TUCIOBMMDDOEMM-RIYZIHGNSA-N
PubChem CID 5328779
IUPAC Name (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
SMILES C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N

Specifications

Quantity 50 mg
Synonym tyrphostin b42, tyrphostin ag 490, e-n-benzyl-2-cyano-3-3,4-dihydroxyphenyl acrylamide, tyrphostin ag490, tyrphostin ag-490, alpha-cyano-3,4-dihydroxy-n-benzylcinnamide, 2e-n-benzyl-2-cyano-3-3,4-dihydroxyphenyl prop-2-enamide, ag-490 tyrphostin b42, n-benzyl-2-cyano-3-3,4-dihydroxyphenyl acrylamide, chembl56543
Formula Weight 294.31
Percent Purity >99%
Chemical Name or Material AG 490
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