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  6. 30001611

ACHP, Tocris Bioscience™

Product Code. 30001611
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Quantity:
10 mg
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Description

Selective IKKα and IKKβ inhibitor

IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis.

Specifications

CAS 406208-42-2
Molecular Formula C21H24N4O2
Quantity 10 mg
Synonym achp, 2-amino-6-2-cyclopropylmethoxy-6-hydroxyphenyl-4-4-pipe
InChI Key DWQVGCQPWXKRKO-JZJYNLBNSA-N
SMILES C1CC1COC2=CC=CC(=O)C2=C3C=C(C(=C(N3)N)C#N)C4CCNCC4
IUPAC Name (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile
Molecular Weight (g/mol) 364.449
PubChem CID 22258733
Formula Weight 364.44
Percent Purity >97%
Chemical Name or Material ACHP
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