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3-Deazaneplanocin A hydrochloride, Tocris Bioscience™
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Quantity:
1 mg
Description
3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).
DZNep synthesized to Ancillary Material Grade also available.
For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs
Specifications
Specifications
| CAS | 120964-45-6 |
| Molecular Formula | C12H15ClN4O3 |
| Quantity | 1 mg |
| Synonym | 3-deazaneplanocin a hydrochloride, 3-deazaneplanocin a dznep hcl, 3-deazaneplanocin, hcl salt, 3-deazaneplanocin a dznep hydrochloride, c12h14n4o3.clh, 3-deazaneplanocin a hydrochloride hplc, --1-1r,4r,5s-3-hydroxymethyl-4,5-dihydroxy-2-cyclopenten-1-yl 4-aminoimidazo 4,5-c pyridinehydrochloridedznephydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl-3-cyclopentene-1,2-diol hydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl cyclopent-3-ene-1,2-diol-hydrogen chloride 1/1 |
| InChI Key | UNSKMHKAFPRFTI-FDKLLANESA-N |
| SMILES | C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl |
| IUPAC Name | (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;hydrochloride |
| Molecular Weight (g/mol) | 298.727 |
| PubChem CID | 14563109 |
| Formula Weight | 298.73 |
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